3DV1
Crystal structure of human beta-secretase in complex with NVP-ARV999
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B, C | Beta-secretase 1 | polymer | 402 | 44777.3 | 3 | UniProt (P56817) Pfam (PF00026) In PDB | Homo sapiens | Beta-site APP cleaving enzyme 1, Beta-site amyloid precursor protein cleaving enzyme 1, Membrane-associated aspartic protease 2, Memapsin-2, Aspartyl protease 2, Asp 2, ASP2 |
2 | A, B, C | (2R,4S)-N-butyl-4-[(2S,5S,7R)-2,7-dimethyl-3,15-dioxo-1,4-diazacyclopentadecan-5-yl]-4-hydroxy-2-methylbutanamide | non-polymer | 439.6 | 3 | Chemie (AR9) | |||
3 | water | water | 18.0 | 525 | Chemie (HOH) |
Sequence modifications
A, B, C: 35 - 386 (UniProt: P56817)
PDB | External Database | Details |
---|---|---|
Gly 33 | - | expression tag |
Pro 34 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 3 |
Total formula weight | 134332.0 | |
Non-Polymers* | Number of molecules | 3 |
Total formula weight | 1318.9 | |
All* | Total formula weight | 135650.9 |