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3DV1

Crystal structure of human beta-secretase in complex with NVP-ARV999

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A, B, CBeta-secretase 1polymer40244777.33UniProt (P56817)
Pfam (PF00026)
In PDB
Homo sapiensBeta-site APP cleaving enzyme 1, Beta-site amyloid precursor protein cleaving enzyme 1, Membrane-associated aspartic protease 2, Memapsin-2, Aspartyl protease 2, Asp 2, ASP2
2A, B, C(2R,4S)-N-butyl-4-[(2S,5S,7R)-2,7-dimethyl-3,15-dioxo-1,4-diazacyclopentadecan-5-yl]-4-hydroxy-2-methylbutanamidenon-polymer439.63Chemie (AR9)
3waterwater18.0525Chemie (HOH)
Sequence modifications
A, B, C: 35 - 386 (UniProt: P56817)
PDBExternal DatabaseDetails
Gly 33-expression tag
Pro 34-expression tag
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains3
Total formula weight134332.0
Non-Polymers*Number of molecules3
Total formula weight1318.9
All*Total formula weight135650.9
*Water molecules are not included.

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PDB entries from 2024-07-10

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