Side-chain fluorine atoms of non-steroidal vitamin D3 analogs stabilize helix 12 of vitamin D receptor

Summary for 3DR1

DescriptorVitamin D3 receptor A, SRC-1 (LXXLL motif) from Nuclear receptor coactivator 1, MAGNESIUM ION, ... (5 entities in total)
Functional Keywordsgene regulation, dna-binding, metal-binding, nucleus, receptor, transcription, transcription regulation, zinc, zinc-finger, activator, acyltransferase, alternative splicing, chromosomal rearrangement, phosphoprotein, polymorphism, proto-oncogene, transferase, ubl conjugation, gene regulation-transferase complex, gene regulation/transferase
Biological sourceDanio rerio (zebra fish)
Cellular locationNucleus Q9PTN2
Nucleus (By similarity) Q15788
Total number of polymer chains2
Total molecular weight36343.55
Sato, Y.,Rochel, N.,Moras, D. (deposition date: 2008-07-10, release date: 2009-06-16, Last modification date: 2011-07-13)
Primary citation
Eelen, G.,Valle, N.,Sato, Y.,Rochel, N.,Verlinden, L.,De Clercq, P.,Moras, D.,Bouillon, R.,Munoz, A.,Verstuyf, A.
Superagonistic fluorinated vitamin D3 analogs stabilize helix 12 of the vitamin D receptor.
Chem.Biol., 15:1029-1034, 2008
PubMed: 18940664 (PDB entries with the same primary citation)
DOI: 10.1016/j.chembiol.2008.08.008
MImport into Mendeley
Experimental method

Structure validation

ClashscoreRamachandran outliersSidechain outliersRSRZ outliers180.8%5.3%2.8%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation report