3DK1
Wild Type HIV-1 Protease with potent Antiviral inhibitor GRL-0105A
Summary for 3DK1
| Entry DOI | 10.2210/pdb3dk1/pdb |
| Related | 2HB3 2IEN 2Z4O 3DJK |
| Descriptor | Protease, SODIUM ION, CHLORIDE ION, ... (5 entities in total) |
| Functional Keywords | hiv-1, wild type protease, protease inhibitor, hydrolase, aids, aspartyl protease, capsid maturation, capsid protein, cytoplasm, dna integration, dna recombination, dna-directed dna polymerase, endonuclease, lipoprotein, magnesium, metal-binding, multifunctional enzyme, myristate, nuclease, nucleotidyltransferase, nucleus, phosphoprotein, protease, ribosomal frameshifting, rna-binding, rna-directed dna polymerase, transferase, viral nucleoprotein, virion, zinc, zinc-finger |
| Biological source | Human immunodeficiency virus type 1 (HIV-1) |
| Cellular location | Gag-Pol polyprotein: Host cell membrane ; Lipid-anchor. Matrix protein p17: Virion membrane; Lipid- anchor . Capsid protein p24: Virion . Nucleocapsid protein p7: Virion . Reverse transcriptase/ribonuclease H: Virion . Integrase: Virion : P03367 |
| Total number of polymer chains | 2 |
| Total formula weight | 22187.40 |
| Authors | Wang, Y.F.,Weber, I.T. (deposition date: 2008-06-24, release date: 2009-05-12, Last modification date: 2023-11-01) |
| Primary citation | Ghosh, A.K.,Gemma, S.,Takayama, J.,Baldridge, A.,Leshchenko-Yashchuk, S.,Miller, H.B.,Wang, Y.F.,Kovalevsky, A.Y.,Koh, Y.,Weber, I.T.,Mitsuya, H. Potent HIV-1 protease inhibitors incorporating meso-bicyclic urethanes as P2-ligands: structure-based design, synthesis, biological evaluation and protein-ligand X-ray studies Org.Biomol.Chem., 6:3703-3713, 2008 Cited by PubMed: 18843400DOI: 10.1039/b809178a PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.07 Å) |
Structure validation
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