3DJT

Crystal structure of transthyretin variant V30M at acidic pH

Summary for 3DJT

Related1F41 2G4E 2NOY 3DJR 3DJS
DescriptorTransthyretin (2 entities in total)
Functional Keywordsttr, amyloid fibrils, point mutation, transport protein, amyloid, disease mutation, gamma-carboxyglutamic acid, glycoprotein, hormone, polyneuropathy, retinol-binding, secreted, thyroid hormone, transport, vitamin a
Biological sourceHOMO SAPIENS (human)
Cellular locationSecreted P02766
Total number of polymer chains2
Total molecular weight27618.85
Authors
Cendron, L.,Zanotti, G.,Folli, C.,Berni, R. (deposition date: 2008-06-24, release date: 2009-07-14, Last modification date: 2014-03-05)
Primary citation
Cendron, L.,Trovato, A.,Seno, F.,Folli, C.,Alfieri, B.,Zanotti, G.,Berni, R.
Amyloidogenic potential of transthyretin variants: insights from structural and computational analyses.
J.Biol.Chem., 284:25832-25841, 2009
PubMed: 19602727 (PDB entries with the same primary citation)
DOI: 10.1074/jbc.M109.017657
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.3 Å)
NMR Information
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.2151104.1%4.3%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution