3DJR

CRYSTAL STRUCTURE OF TRANSTHYRETIN VARIANT L58H at neutral pH

Summary for 3DJR

Related1F41 2G4E 2NOY 3DJS 3DJT 3DJZ 3DK0 3DK2
DescriptorTransthyretin (2 entities in total)
Functional Keywordsttr, amyloid fibrils, point mutation, transport protein, amyloid, disease mutation, gamma-carboxyglutamic acid, glycoprotein, hormone, polyneuropathy, retinol-binding, secreted, thyroid hormone, transport, vitamin a
Biological sourceHomo sapiens (Human)
Cellular locationSecreted P02766
Total number of polymer chains2
Total molecular weight27604.7
Authors
Cendron, L.,Zanotti, G.,Folli, C.,Berni, R. (deposition date: 2008-06-24, release date: 2009-07-14, Last modification date: 2014-03-05)
Primary citation
Cendron, L.,Trovato, A.,Seno, F.,Folli, C.,Alfieri, B.,Zanotti, G.,Berni, R.
Amyloidogenic potential of transthyretin variants: insights from structural and computational analyses.
J.Biol.Chem., 284:25832-25841, 2009
PubMed: 19602727 (PDB entries with the same primary citation)
DOI: 10.1074/jbc.M109.017657
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.02 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.22813 0.9% 7.8% 20.0%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation reportDownload
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PDB entries from 2020-10-28