3D84

Structural Analysis of a Holo Enzyme Complex of Mouse Dihydrofolate Reductase with NADPH and a Ternary Complex with the Potent and Selective Inhibitor 2.4-Diamino-6-(-2'-hydroxydibenz[b,f]azepin-5-yl)methylpteridine

3D84 の概要

• エントリーDOI: 10.2210/pdb3d84/pdb
• 関連するPDBエントリー: 2FZJ 3D7X 3D7Y 3D80
• 分子名称: Dihydrofolate reductase, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, GLYCEROL, ... (4 entities in total)
• 機能のキーワード: mouse dhfr holo enzyme and ternary ligand complex, nadp, one-carbon metabolism, oxidoreductase
• 由来する生物種: Mus musculus (mouse)
• 細胞内の位置: Mitochondrion : P00375
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 22433.45

構造登録者

Cody, V. (登録日: 2008-05-22, 公開日: 2008-09-23, 最終更新日: 2023-08-30)

• 主引用文献: Cody, V.,Pace, J.,Rosowsky, A.; Structural analysis of a holoenzyme complex of mouse dihydrofolate reductase with NADPH and a ternary complex with the potent and selective inhibitor 2,4-diamino-6-(2'-hydroxydibenz[b,f]azepin-5-yl)methylpteridine.; Acta Crystallogr.,Sect.D, 64:977-984, 2008; PubMed: 18703847; DOI: 10.1107/S0907444908022348

実験手法