3D84

Structural Analysis of a Holo Enzyme Complex of Mouse Dihydrofolate Reductase with NADPH and a Ternary Complex with the Potent and Selective Inhibitor 2.4-Diamino-6-(-2'-hydroxydibenz[b,f]azepin-5-yl)methylpteridine

Summary for 3D84

Entry DOI	10.2210/pdb3d84/pdb
Related	2FZJ 3D7X 3D7Y 3D80
Descriptor	Dihydrofolate reductase, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, GLYCEROL, ... (4 entities in total)
Functional Keywords	mouse dhfr holo enzyme and ternary ligand complex, nadp, one-carbon metabolism, oxidoreductase
Biological source	Mus musculus (mouse)
Cellular location	Mitochondrion : P00375
Total number of polymer chains	1
Total formula weight	22433.45
Authors	Cody, V. (deposition date: 2008-05-22, release date: 2008-09-23, Last modification date: 2023-08-30)
Primary citation	Cody, V.,Pace, J.,Rosowsky, A. Structural analysis of a holoenzyme complex of mouse dihydrofolate reductase with NADPH and a ternary complex with the potent and selective inhibitor 2,4-diamino-6-(2'-hydroxydibenz[b,f]azepin-5-yl)methylpteridine. Acta Crystallogr.,Sect.D, 64:977-984, 2008 Cited by PubMed: 18703847 DOI: 10.1107/S0907444908022348 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.9 Å)

Structure validation