3D80

Structural Analysis of a Holo Enzyme Complex of Mouse Dihydrofolate Reductase with NADPH and a Ternary Complex wtih the Potent and Selective Inhibitor 2,4-Diamino-6-(2'-hydroxydibenz[b,f]azepin-5-yl)methylpteridine

Summary for 3D80

Entry DOI	10.2210/pdb3d80/pdb
Related	2FZJ 3D7X 3D7Y 3D84
Descriptor	Dihydrofolate reductase, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, (4aS)-5-[(2,4-diaminopteridin-6-yl)methyl]-4a,5-dihydro-2H-dibenzo[b,f]azepin-8-ol, ... (5 entities in total)
Functional Keywords	mouse holo enzyme ternary ligand complex dihydrofolate reductase, nadp, one-carbon metabolism, oxidoreductase
Biological source	Mus musculus (mouse)
Total number of polymer chains	1
Total formula weight	22910.97
Authors	Cody, V. (deposition date: 2008-05-22, release date: 2008-09-23, Last modification date: 2023-08-30)
Primary citation	Cody, V.,Pace, J.,Rosowsky, A. Structural analysis of a holoenzyme complex of mouse dihydrofolate reductase with NADPH and a ternary complex with the potent and selective inhibitor 2,4-diamino-6-(2'-hydroxydibenz[b,f]azepin-5-yl)methylpteridine. Acta Crystallogr.,Sect.D, 64:977-984, 2008 Cited by PubMed: 18703847 DOI: 10.1107/S0907444908022348 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.4 Å)

Structure validation