3D80
Structural Analysis of a Holo Enzyme Complex of Mouse Dihydrofolate Reductase with NADPH and a Ternary Complex wtih the Potent and Selective Inhibitor 2,4-Diamino-6-(2'-hydroxydibenz[b,f]azepin-5-yl)methylpteridine
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Dihydrofolate reductase | polymer | 186 | 21503.8 | 1 | UniProt (P00375) Pfam (PF00186) In PDB | Mus musculus (mouse) | |
| 2 | A | NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | non-polymer | 745.4 | 1 | Chemie (NDP) | |||
| 3 | A | (4aS)-5-[(2,4-diaminopteridin-6-yl)methyl]-4a,5-dihydro-2H-dibenzo[b,f]azepin-8-ol | non-polymer | 385.4 | 1 | Chemie (Q22) | |||
| 4 | A | GLYCEROL | non-polymer | 92.1 | 3 | Chemie (GOL) | |||
| 5 | water | water | 18.0 | 316 | Chemie (HOH) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 21503.8 | |
| Non-Polymers* | Number of molecules | 5 |
| Total formula weight | 1407.1 | |
| All* | Total formula weight | 22911.0 |
