3D6G

Fc fragment of IgG1 (Herceptin) with protein-A mimetic peptide dendrimer ligand.

Summary for 3D6G

• Entry DOI: 10.2210/pdb3d6g/pdb
• Related: 1HZH 1L6X 2DTQ
• Descriptor: Ig gamma-1 chain C region, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, 2-[[(2S)-2,6-bis[[(2S)-2,6-bis[[(2R)-2-[[(2R,3R)-2-[[(2R)-2-amino-5-carbamimidamido-pentanoyl]amino]-3-hydroxy-butanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]hexanoyl]amino]hexanoyl]amino]ethanoic acid, ... (4 entities in total)
• Functional Keywords: fc fragment, igg1, glycosilated protein, protein a mimetic peptide dendrimer ligand, glycoprotein, immunoglobulin c region, immunoglobulin domain, secreted, immune system
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 2
• Total formula weight: 52645.82

Authors

Bujacz, A.D.,Redzynia, I.,Bujacz, G.D.,Dinon, F.,Pengo, P.,Fassina, G. (deposition date: 2008-05-19, release date: 2009-06-16, Last modification date: 2023-11-01)

• Primary citation: Moiani, D.,Salvalaglio, M.,Cavallotti, C.,Bujacz, A.,Redzynia, I.,Bujacz, G.,Dinon, F.,Pengo, P.,Fassina, G.; Structural characterization of a Protein A mimetic peptide dendrimer bound to human IgG.; J.Phys.Chem.B, 113:16268-16275, 2009; PubMed: 19924842; DOI: 10.1021/jp909405b

Experimental method

X-RAY DIFFRACTION (2.3 Å)