3D4B

Crystal structure of Sir2Tm in complex with Acetyl p53 peptide and DADMe-NAD+

3D4B の概要

• エントリーDOI: 10.2210/pdb3d4b/pdb
• 分子名称: NAD-dependent deacetylase, Acetyl P53 peptide, ZINC ION, ... (5 entities in total)
• 機能のキーワード: rossmann fold, cytoplasm, hydrolase, metal-binding, nad, zinc
• 由来する生物種: Thermotoga maritima
• 細胞内の位置: Cytoplasm (Probable): Q9WYW0
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 29409.07

構造登録者

Hawse, W.F.,Hoff, K.G.,Fatkins, D.,Daines, A.,Zubkova, O.V.,Schramm, V.L.,Zheng, W.,Wolberger, C. (登録日: 2008-05-14, 公開日: 2008-09-30, 最終更新日: 2011-07-13)

• 主引用文献: Hawse, W.F.,Hoff, K.G.,Fatkins, D.G.,Daines, A.,Zubkova, O.V.,Schramm, V.L.,Zheng, W.,Wolberger, C.; Structural insights into intermediate steps in the Sir2 deacetylation reaction.; Structure, 16:1368-1377, 2008; PubMed: 18786399; DOI: 10.1016/j.str.2008.05.015

実験手法

X-RAY DIFFRACTION (1.9 Å)