3D3V

The complex between TCR A6 and human Class I MHC HLA-A2 with the modified HTLV-1 TAX (Y5(3,4-difluoroPhenylalanine)) peptide

Summary for 3D3V

Entry DOI	10.2210/pdb3d3v/pdb
Related	1AO7 1QRN 1QSE 1QSF 2GJ6 3D39
Descriptor	HLA class I histocompatibility antigen, A-2 alpha chain, Beta-2-microglobulin, Modified HTLV-1 TAX (Y5(3,4-difluoro)F) peptide, ... (7 entities in total)
Functional Keywords	htlv-1 tax peptide, 3, 4-difluorophenylalanine, mhc class i, hla-a2, t-cell receptor a6, glycoprotein, host-virus interaction, immune response, membrane, mhc i, phosphoprotein, transmembrane, immunoglobulin domain, secreted, disease mutation, glycation, pyrrolidone carboxylic acid, immune system
Biological source	Homo sapiens More
Cellular location	Membrane; Single-pass type I membrane protein: P01892 Secreted : P61769
Total number of polymer chains	5
Total formula weight	94824.93
Authors	Borbulevych, O.Y.,Clemens, J.R.,Baker, B.M. (deposition date: 2008-05-12, release date: 2009-06-16, Last modification date: 2023-11-15)
Primary citation	Piepenbrink, K.H.,Borbulevych, O.Y.,Sommese, R.F.,Clemens, J.,Armstrong, K.M.,Desmond, C.,Do, P.,Baker, B.M. Fluorine substitutions in an antigenic peptide selectively modulate T-cell receptor binding in a minimally perturbing manner. Biochem.J., 423:353-361, 2009 Cited by PubMed: 19698083 DOI: 10.1042/BJ20090732 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.8 Å)

Structure validation