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3D39

The complex between TCR A6 and human Class I MHC HLA-A2 with the modified HTLV-1 TAX (Y5(4-fluoroPhenylalanine)) peptide

Summary for 3D39
Entry DOI10.2210/pdb3d39/pdb
Related1AO7 1QRN 1QSE 1QSF 2GJ6 3D3V
DescriptorHLA class I histocompatibility antigen, A-2 alpha chain, Beta-2-microglobulin, Modified HTLV-1 TAX (Y5(4fluoro)F) peptide, ... (7 entities in total)
Functional Keywordshtlv-1 tax peptide, 4-fluorophenylalanine, mhc class i, hla-a2, t-cell receptor a6, glycoprotein, host-virus interaction, immune response, membrane, mhc i, phosphoprotein, transmembrane, disease mutation, glycation, immunoglobulin domain, pyrrolidone carboxylic acid, secreted, immune system
Biological sourceHomo sapiens
More
Cellular locationMembrane; Single-pass type I membrane protein: P01892
Secreted: P61769
Total number of polymer chains5
Total formula weight94622.75
Authors
Borbulevych, O.Y.,Clemens, J.R.,Baker, B.M. (deposition date: 2008-05-09, release date: 2009-06-16, Last modification date: 2023-08-30)
Primary citationPiepenbrink, K.H.,Borbulevych, O.Y.,Sommese, R.F.,Clemens, J.,Armstrong, K.M.,Desmond, C.,Do, P.,Baker, B.M.
Fluorine substitutions in an antigenic peptide selectively modulate T-cell receptor binding in a minimally perturbing manner
Biochem.J., 423:353-361, 2009
Cited by
PubMed: 19698083
DOI: 10.1042/BJ20090732
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.81 Å)
Structure validation

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