3D1Y

Crystal structure of HIV-1 mutant I54V and inhibitor SAQUINA

Summary for 3D1Y

Entry DOI	10.2210/pdb3d1y/pdb
Related	3CYW 3CYX 3D1X 3D1Z 3D20
Related PRD ID	PRD_000454
Descriptor	HIV-1 Protease, SODIUM ION, CHLORIDE ION, ... (5 entities in total)
Functional Keywords	drug resistance, hiv-1, i54v, flap mutant, aids, aspartyl protease, capsid maturation, capsid protein, protease, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological source	Human immunodeficiency virus type 1 (HIV-1)
Cellular location	Matrix protein p17: Virion (Potential). Capsid protein p24: Virion (Potential). Nucleocapsid protein p7: Virion (Potential). Reverse transcriptase/ribonuclease H: Virion (Potential). Integrase: Virion (Potential): P04587
Total number of polymer chains	2
Total formula weight	22218.03
Authors	Liu, F.,Weber, I.T. (deposition date: 2008-05-06, release date: 2008-05-27, Last modification date: 2024-02-21)
Primary citation	Liu, F.,Kovalevsky, A.Y.,Tie, Y.,Ghosh, A.K.,Harrison, R.W.,Weber, I.T. Effect of flap mutations on structure of HIV-1 protease and inhibition by saquinavir and darunavir. J.Mol.Biol., 381:102-115, 2008 Cited by PubMed: 18597780 DOI: 10.1016/j.jmb.2008.05.062 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.05 Å)

Structure validation