3CYW

Effect of Flap Mutations on Structure of HIV-1 Protease and Inhibition by Saquinavir and Darunavir

Summary for 3CYW

• Entry DOI: 10.2210/pdb3cyw/pdb
• Related: 3CYX
• Descriptor: HIV-1 Protease, CHLORIDE ION, (3R,3AS,6AR)-HEXAHYDROFURO[2,3-B]FURAN-3-YL(1S,2R)-3-[[(4-AMINOPHENYL)SULFONYL](ISOBUTYL)AMINO]-1-BENZYL-2-HYDROXYPROPYLCARBAMATE, ... (5 entities in total)
• Functional Keywords: drug resistance; hiv-1, aids, aspartyl protease, capsid maturation, capsid protein, dna integration, dna recombination, dna-directed dna polymerase, endonuclease, hydrolase, lipoprotein, magnesium, membrane, metal-binding, multifunctional enzyme, myristate, nuclease, nucleotidyltransferase, nucleus, phosphoprotein, protease, rna-binding, rna-directed dna polymerase, transferase, viral nucleoprotein, virion, zinc-finger
• Biological source: Human immunodeficiency virus type 1
• Cellular location: Matrix protein p17: Virion (Potential). Capsid protein p24: Virion (Potential). Nucleocapsid protein p7: Virion (Potential). Reverse transcriptase/ribonuclease H: Virion (Potential). Integrase: Virion (Potential): P04587
• Total number of polymer chains: 2
• Total formula weight: 22382.53

Authors

Liu, F.,Weber, I.T. (deposition date: 2008-04-27, release date: 2008-05-27, Last modification date: 2023-08-30)

• Primary citation: Liu, F.,Kovalevsky, A.Y.,Tie, Y.,Ghosh, A.K.,Harrison, R.W.,Weber, I.T.; Effect of flap mutations on structure of HIV-1 protease and inhibition by saquinavir and darunavir.; J.Mol.Biol., 381:102-115, 2008; PubMed: 18597780; DOI: 10.1016/j.jmb.2008.05.062

Experimental method

X-RAY DIFFRACTION (1.4 Å)