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3CYW

Effect of Flap Mutations on Structure of HIV-1 Protease and Inhibition by Saquinavir and Darunavir

Functional Information from GO Data
ChainGOidnamespacecontents
A0004190molecular_functionaspartic-type endopeptidase activity
A0006508biological_processproteolysis
B0004190molecular_functionaspartic-type endopeptidase activity
B0006508biological_processproteolysis
Functional Information from PDB Data
site_idAC1
Number of Residues3
DetailsBINDING SITE FOR RESIDUE CL A 602
ChainResidue
ATHR74
AASN88
BARG41

site_idAC2
Number of Residues2
DetailsBINDING SITE FOR RESIDUE CL B 603
ChainResidue
BTHR74
BASN88

site_idAC3
Number of Residues3
DetailsBINDING SITE FOR RESIDUE CL A 604
ChainResidue
AALA95
BTHR4
BLEU5

site_idAC4
Number of Residues4
DetailsBINDING SITE FOR RESIDUE CL A 605
ChainResidue
AILE72
AGLN92
BGLY40
AALA71

site_idAC5
Number of Residues19
DetailsBINDING SITE FOR RESIDUE 017 A 201
ChainResidue
ALEU23
AASP25
AGLY27
AALA28
AASP29
AASP30
AGLY49
AILE50
APRO81
AILE84
BASP25
BGLY27
BALA28
BASP29
BASP30
BGLY49
BILE50
BPRO81
BILE84

site_idAC6
Number of Residues3
DetailsBINDING SITE FOR RESIDUE GOL A 501
ChainResidue
ATRP6
APHE53
BTHR91

Functional Information from PROSITE/UniProt
site_idPS00141
Number of Residues12
DetailsASP_PROTEASE Eukaryotic and viral aspartyl proteases active site. ALLDTGADDTVI
ChainResidueDetails
AALA22-ILE33

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2
DetailsACT_SITE: For protease activity; shared with dimeric partner => ECO:0000255|PROSITE-ProRule:PRU10094
ChainResidueDetails
AASP25
BASP25

site_idSWS_FT_FI2
Number of Residues2
DetailsSITE: Cleavage; by viral protease => ECO:0000250
ChainResidueDetails
APHE99
BPHE99

Catalytic Information from CSA
site_idCSA1
Number of Residues2
DetailsAnnotated By Reference To The Literature 1a30
ChainResidueDetails
AASP25
ATHR26

site_idCSA2
Number of Residues2
DetailsAnnotated By Reference To The Literature 1a30
ChainResidueDetails
BASP25
BTHR26

site_idCSA3
Number of Residues1
DetailsAnnotated By Reference To The Literature 1a30
ChainResidueDetails
AASP25

site_idCSA4
Number of Residues1
DetailsAnnotated By Reference To The Literature 1a30
ChainResidueDetails
BASP25

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PDB entries from 2024-11-06

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