3CYX

Crystal structure of HIV-1 mutant I50V and inhibitor saquinavira

Summary for 3CYX

• Entry DOI: 10.2210/pdb3cyx/pdb
• Related: 3CYW
• Related PRD ID: PRD_000454
• Descriptor: HIV-1 Protease, (2S)-N-[(2S,3R)-4-[(2S,3S,4aS,8aS)-3-(tert-butylcarbamoyl)-3,4,4a,5,6,7,8,8a-octahydro-1H-isoquinolin-2-yl]-3-hydroxy-1 -phenyl-butan-2-yl]-2-(quinolin-2-ylcarbonylamino)butanediamide, SODIUM ION, ... (7 entities in total)
• Functional Keywords: drug resistance; hiv-1, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• Biological source: Human immunodeficiency virus 1
• Cellular location: Matrix protein p17: Virion (Potential). Capsid protein p24: Virion (Potential). Nucleocapsid protein p7: Virion (Potential). Reverse transcriptase/ribonuclease H: Virion (Potential). Integrase: Virion (Potential): P04587
• Total number of polymer chains: 2
• Total formula weight: 22394.25

Authors

Liu, F.,Weber, I.T. (deposition date: 2008-04-27, release date: 2008-05-27, Last modification date: 2023-08-30)

• Primary citation: Liu, F.,Kovalevsky, A.Y.,Tie, Y.,Ghosh, A.K.,Harrison, R.W.,Weber, I.T.; Effect of flap mutations on structure of HIV-1 protease and inhibition by saquinavir and darunavir.; J.Mol.Biol., 381:102-115, 2008; PubMed: 18597780; DOI: 10.1016/j.jmb.2008.05.062

Experimental method

X-RAY DIFFRACTION (1.2 Å)