3CV9

Crystal structure of vitamin D hydroxylase cytochrome P450 105A1 (R73A/R84A mutant) in complex with 1alpha,25-dihydroxyvitamin D3

3CV9 の概要

• エントリーDOI: 10.2210/pdb3cv9/pdb
• 関連するPDBエントリー: 2ZBX 2ZBY 2ZBZ 3CV8
• 分子名称: Cytochrome P450-SU1, PROTOPORPHYRIN IX CONTAINING FE, 5-{2-[1-(5-HYDROXY-1,5-DIMETHYL-HEXYL)-7A-METHYL-OCTAHYDRO-INDEN-4-YLIDENE]-ETHYLIDENE}-4-METHYLENE-CYCLOHEXANE-1,3-DIOL, ... (4 entities in total)
• 機能のキーワード: p450, beta prism, heme, iron, metal-binding, monooxygenase, oxidoreductase
• 由来する生物種: Streptomyces griseolus
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 45938.75

構造登録者

Hayashi, K.,Sugimoto, H.,Shinkyo, R.,Yamada, M.,Ikeda, S.,Ikushiro, S.,Kamakura, M.,Shiro, Y.,Sakaki, T. (登録日: 2008-04-18, 公開日: 2008-11-04, 最終更新日: 2023-11-01)

• 主引用文献: Hayashi, K.,Sugimoto, H.,Shinkyo, R.,Yamada, M.,Ikeda, S.,Ikushiro, S.,Kamakura, M.,Shiro, Y.,Sakaki, T.; Structure-based design of a highly active vitamin D hydroxylase from Streptomyces griseolus CYP105A1; Biochemistry, 47:11964-11972, 2008; PubMed: 18937506; DOI: 10.1021/bi801222d

実験手法

X-RAY DIFFRACTION (1.7 Å)