3CTJ

Crystal structure of the tyrosine kinase domain of the hepatocyte growth factor receptor c-met in complex with a aminopyridine based inhibitor

3CTJ の概要

• エントリーDOI: 10.2210/pdb3ctj/pdb
• 関連するPDBエントリー: 3C1X 3CTH 3CTK
• 分子名称: Hepatocyte growth factor receptor, 2-(4-fluorophenyl)-N-{[3-fluoro-4-(1H-pyrrolo[2,3-b]pyridin-4-yloxy)phenyl]carbamoyl}acetamide (3 entities in total)
• 機能のキーワード: receptor tyrosine kinase, signal transduction, grb2, shc, atp-binding, glycoprotein, membrane, nucleotide-binding, phosphoprotein, proto-oncogene, transferase, transmembrane, tyrosine-protein kinase
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Membrane; Single-pass type I membrane protein: P08581
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 35857.42

構造登録者

Sack, J. (登録日: 2008-04-14, 公開日: 2008-06-10, 最終更新日: 2024-02-21)

• 主引用文献: Cai, Z.-W.,Wei, D.,Schroeder, G.M.,Cornelius, L.A.,Kim, K.,Chen, X.-T.,Schmidt, R.J.,Williams, D.K.,Tokarski, J.S.,An, Y.,Sack, J.S.,Manne, V.,Kamath, A.,Zhang, Y.,Marathe, P.,Hunt, J.T.,Lombardo, L.J.,Fargnoli, J.,Borzilleri, R.M.; Discovery of orally active pyrrolopyridine- and aminopyridine-based Met kinase inhibitors; Bioorg.Med.Chem.Lett., 18:3224-3229, 2008; PubMed: 18479916; DOI: 10.1016/j.bmcl.2008.04.047

実験手法

X-RAY DIFFRACTION (2.5 Å)