3CP6

Crystal structure of human farnesyl diphosphate synthase (T201A mutant) complexed with Mg and biphosphonate inhibitor

Summary for 3CP6

• Entry DOI: 10.2210/pdb3cp6/pdb
• Related: 1YQ7 1YV5 1ZW5 2QIS 3B7L
• Descriptor: Farnesyl pyrophosphate synthetase, MAGNESIUM ION, (4aS,7aR)-octahydro-1H-cyclopenta[b]pyridine-6,6-diylbis(phosphonic acid), ... (4 entities in total)
• Functional Keywords: isoprenoid pathway, cholesterol synthesis, bisphosphonate, structural genomics, structural genomics consortium, sgc, cholesterol biosynthesis, host-virus interaction isoprene biosynthesis, lipid synthesis, steroid biosynthesis, sterol biosynthesis, transferase
• Biological source: Homo sapiens (human)
• Cellular location: Cytoplasm: P14324
• Total number of polymer chains: 1
• Total formula weight: 43604.24

Authors

Pilka, E.S.,Dunford, J.E.,Guo, K.,Pike, A.C.W.,von Delft, F.,Barnett, B.L.,Ebetino, F.H.,Arrowsmith, C.H.,Bountra, C.,Edwards, A.M.,Russell, R.G.G.,Oppermann, U.,Structural Genomics Consortium (SGC) (deposition date: 2008-03-31, release date: 2008-04-15, Last modification date: 2023-09-20)

• Primary citation: Pilka, E.S.,Dunford, J.E.,Guo, K.,Pike, A.C.W.,von Delft, F.,Barnett, B.L.,Ebetino, F.H.,Arrowsmith, C.H.,Bountra, C.,Edwards, A.M.,Russell, R.G.G.,Oppermann, U.; Human farnesyl diphosphate synthase (T201A mutant) complexed with Mg and biphosphonate inhibitor.; To be Published,

Experimental method

X-RAY DIFFRACTION (1.95 Å)