3CP6
Crystal structure of human farnesyl diphosphate synthase (T201A mutant) complexed with Mg and biphosphonate inhibitor
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Farnesyl pyrophosphate synthetase | polymer | 376 | 43246.2 | 1 | UniProt (P14324) Pfam (PF00348) In PDB | Homo sapiens (human) | (FPP synthetase) (FPS) (Farnesyl diphosphate synthetase) [Includes: Dimethylallyltranstransferase (EC 2.5.1.1); Geranyltranstransferase (EC 2.5.1.10)] |
2 | A | MAGNESIUM ION | non-polymer | 24.3 | 3 | Chemie (MG) | |||
3 | A | (4aS,7aR)-octahydro-1H-cyclopenta[b]pyridine-6,6-diylbis(phosphonic acid) | non-polymer | 285.2 | 1 | Chemie (RSX) | |||
4 | water | water | 18.0 | 210 | Chemie (HOH) |
Sequence modifications
A: 1 - 353 (UniProt: P14324)
PDB | External Database | Details |
---|---|---|
Met -22 | - | expression tag |
Gly -21 | - | expression tag |
Ser -20 | - | expression tag |
Ser -19 | - | expression tag |
His -18 | - | expression tag |
His -17 | - | expression tag |
His -16 | - | expression tag |
His -15 | - | expression tag |
His -14 | - | expression tag |
His -13 | - | expression tag |
Ser -12 | - | expression tag |
Ser -11 | - | expression tag |
Gly -10 | - | expression tag |
Arg -9 | - | expression tag |
Glu -8 | - | expression tag |
Asn -7 | - | expression tag |
Leu -6 | - | expression tag |
Tyr -5 | - | expression tag |
Phe -4 | - | expression tag |
Gln -3 | - | expression tag |
Gly -2 | - | expression tag |
His -1 | - | expression tag |
Met 0 | - | expression tag |
Ala 201 | Thr 201 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 1 |
Total formula weight | 43246.2 | |
Non-Polymers* | Number of molecules | 4 |
Total formula weight | 358.1 | |
All* | Total formula weight | 43604.2 |