3CP6
Crystal structure of human farnesyl diphosphate synthase (T201A mutant) complexed with Mg and biphosphonate inhibitor
3CP6 の概要
エントリーDOI | 10.2210/pdb3cp6/pdb |
関連するPDBエントリー | 1YQ7 1YV5 1ZW5 2QIS 3B7L |
分子名称 | Farnesyl pyrophosphate synthetase, MAGNESIUM ION, (4aS,7aR)-octahydro-1H-cyclopenta[b]pyridine-6,6-diylbis(phosphonic acid), ... (4 entities in total) |
機能のキーワード | isoprenoid pathway, cholesterol synthesis, bisphosphonate, structural genomics, structural genomics consortium, sgc, cholesterol biosynthesis, host-virus interaction isoprene biosynthesis, lipid synthesis, steroid biosynthesis, sterol biosynthesis, transferase |
由来する生物種 | Homo sapiens (human) |
細胞内の位置 | Cytoplasm: P14324 |
タンパク質・核酸の鎖数 | 1 |
化学式量合計 | 43604.24 |
構造登録者 | Pilka, E.S.,Dunford, J.E.,Guo, K.,Pike, A.C.W.,von Delft, F.,Barnett, B.L.,Ebetino, F.H.,Arrowsmith, C.H.,Bountra, C.,Edwards, A.M.,Russell, R.G.G.,Oppermann, U.,Structural Genomics Consortium (SGC) (登録日: 2008-03-31, 公開日: 2008-04-15, 最終更新日: 2023-09-20) |
主引用文献 | Pilka, E.S.,Dunford, J.E.,Guo, K.,Pike, A.C.W.,von Delft, F.,Barnett, B.L.,Ebetino, F.H.,Arrowsmith, C.H.,Bountra, C.,Edwards, A.M.,Russell, R.G.G.,Oppermann, U. Human farnesyl diphosphate synthase (T201A mutant) complexed with Mg and biphosphonate inhibitor. To be Published, |
実験手法 | X-RAY DIFFRACTION (1.95 Å) |
構造検証レポート
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