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3CP6

Crystal structure of human farnesyl diphosphate synthase (T201A mutant) complexed with Mg and biphosphonate inhibitor

3CP6 の概要
エントリーDOI10.2210/pdb3cp6/pdb
関連するPDBエントリー1YQ7 1YV5 1ZW5 2QIS 3B7L
分子名称Farnesyl pyrophosphate synthetase, MAGNESIUM ION, (4aS,7aR)-octahydro-1H-cyclopenta[b]pyridine-6,6-diylbis(phosphonic acid), ... (4 entities in total)
機能のキーワードisoprenoid pathway, cholesterol synthesis, bisphosphonate, structural genomics, structural genomics consortium, sgc, cholesterol biosynthesis, host-virus interaction isoprene biosynthesis, lipid synthesis, steroid biosynthesis, sterol biosynthesis, transferase
由来する生物種Homo sapiens (human)
細胞内の位置Cytoplasm: P14324
タンパク質・核酸の鎖数1
化学式量合計43604.24
構造登録者
主引用文献Pilka, E.S.,Dunford, J.E.,Guo, K.,Pike, A.C.W.,von Delft, F.,Barnett, B.L.,Ebetino, F.H.,Arrowsmith, C.H.,Bountra, C.,Edwards, A.M.,Russell, R.G.G.,Oppermann, U.
Human farnesyl diphosphate synthase (T201A mutant) complexed with Mg and biphosphonate inhibitor.
To be Published,
実験手法
X-RAY DIFFRACTION (1.95 Å)
構造検証レポート
Validation report summary of 3cp6
検証レポート(詳細版)ダウンロードをダウンロード

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件を2024-03-27に公開中

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