3COA

Crystal Structure of FoxO1 DBD Bound to IRE DNA

Summary for 3COA

Related3CO6 3CO7
DescriptorDNA (5'-D(*DTP*DGP*DGP*DTP*DTP*DTP*DGP*DTP*DTP*DTP*DTP*DGP*DCP*DTP*DTP*DG)-3'), DNA (5'-D(*DCP*DAP*DAP*DGP*DCP*DAP*DAP*DAP*DAP*DCP*DAP*DAP*DAP*DCP*DCP*DA)-3'), Forkhead box protein O1, ... (5 entities in total)
Functional Keywordswinged helix, forkhead domain, chromosomal rearrangement, cytoplasm, dna-binding, nucleus, phosphoprotein, proto-oncogene, transcription, transcription regulation, transcription-dna complex, transcription/dna
Biological sourceHomo sapiens (Human)
Cellular locationCytoplasm  Q12778
Total number of polymer chains6
Total molecular weight45976.46
Authors
Brent, M.M.,Anand, R.,Marmorstein, R. (deposition date: 2008-03-27, release date: 2008-09-16, Last modification date: 2017-10-25)
Primary citation
Brent, M.M.,Anand, R.,Marmorstein, R.
Structural Basis for DNA Recognition by FoxO1 and Its Regulation by Posttranslational Modification.
Structure, 16:1407-1416, 2008
PubMed: 18786403 (PDB entries with the same primary citation)
DOI: 10.1016/j.str.2008.06.013
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.2 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.256140.6%2.1%5.9%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

Molmil generated image of 3coa
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Molmil generated image of 3coa
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Molmil generated image of 3coa
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More Biological unit images

Molmil generated image of 3coa
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Molmil generated image of 3coa
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Molmil generated image of 3coa
rotated about y axis by 90°
(*)In the case of coarse surface representation, the asymmetric unit is shown as red ribbon representation.
Coordinate files for Biological unit (3coa.pdb1.gz [30.03 KB])
Coordinate files for Biological unit (3coa.pdb2.gz [30.44 KB])