3CJF

Crystal structure of VEGFR2 in complex with a 3,4,5-trimethoxy aniline containing pyrimidine

3CJF の概要

• エントリーDOI: 10.2210/pdb3cjf/pdb
• 関連するPDBエントリー: 1VR2 1Y6A 1Y6B 1ywn 3CJG
• 分子名称: Vascular endothelial growth factor receptor 2, SULFATE ION, N~4~-(3-methyl-1H-indazol-6-yl)-N~2~-(3,4,5-trimethoxyphenyl)pyrimidine-2,4-diamine, ... (4 entities in total)
• 機能のキーワード: vascular endothelial growth factor receptor 2. vegfr-2, kinase insert domain receptor, protein-tyrosine kinase receptor flk-1, angiogenesis, atp-binding, developmental protein, differentiation, glycoprotein, host-virus interaction, immunoglobulin domain, membrane, nucleotide-binding, phosphoprotein, transferase, transmembrane, tyrosine-protein kinase
• 由来する生物種: Homo sapiens (human); 詳細
• 細胞内の位置: Cell junction . Isoform 1: Cell membrane; Single-pass type I membrane protein. Isoform 2: Secreted . Isoform 3: Secreted: P35968
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 36282.60

構造登録者

Nolte, R.T. (登録日: 2008-03-12, 公開日: 2008-10-07, 最終更新日: 2024-10-30)

主引用文献

Harris, P.A.,Boloor, A.,Cheung, M.,Kumar, R.,Crosby, R.M.,Davis-Ward, R.G.,Epperly, A.H.,Hinkle, K.W.,Hunter, R.N.,Johnson, J.H.,Knick, V.B.,Laudeman, C.P.,Luttrell, D.K.,Mook, R.A.,Nolte, R.T.,Rudolph, S.K.,Szewczyk, J.R.,Truesdale, A.T.,Veal, J.M.,Wang, L.,Stafford, J.A.
Discovery of 5-[[4-[(2,3-dimethyl-2H-indazol-6-yl)methylamino]-2-pyrimidinyl]amino]-2-methyl-benzenesulfonamide (Pazopanib), a novel and potent vascular endothelial growth factor receptor inhibitor.
J.Med.Chem., 51:4632-4640, 2008

PubMed Abstract: Inhibition of the vascular endothelial growth factor (VEGF) signaling pathway has emerged as one of the most promising new approaches for cancer therapy. We describe herein the key steps starting from an initial screening hit leading to the discovery of pazopanib, N(4)-(2,3-dimethyl-2H-indazol-6-yl)-N(4)-methyl-N(2)-(4-methyl-3-sulfonamidophenyl)-2,4-pyrimidinediamine, a potent pan-VEGF receptor (VEGFR) inhibitor under clinical development for renal-cell cancer and other solid tumors.

PubMed: 18620382
DOI: 10.1021/jm800566m

実験手法

X-RAY DIFFRACTION (2.15 Å)