3CJF
Crystal structure of VEGFR2 in complex with a 3,4,5-trimethoxy aniline containing pyrimidine
3CJF の概要
エントリーDOI | 10.2210/pdb3cjf/pdb |
関連するPDBエントリー | 1VR2 1Y6A 1Y6B 1ywn 3CJG |
分子名称 | Vascular endothelial growth factor receptor 2, SULFATE ION, N~4~-(3-methyl-1H-indazol-6-yl)-N~2~-(3,4,5-trimethoxyphenyl)pyrimidine-2,4-diamine, ... (4 entities in total) |
機能のキーワード | vascular endothelial growth factor receptor 2. vegfr-2, kinase insert domain receptor, protein-tyrosine kinase receptor flk-1, angiogenesis, atp-binding, developmental protein, differentiation, glycoprotein, host-virus interaction, immunoglobulin domain, membrane, nucleotide-binding, phosphoprotein, transferase, transmembrane, tyrosine-protein kinase |
由来する生物種 | Homo sapiens (human) 詳細 |
細胞内の位置 | Cell junction . Isoform 1: Cell membrane; Single-pass type I membrane protein. Isoform 2: Secreted . Isoform 3: Secreted: P35968 |
タンパク質・核酸の鎖数 | 1 |
化学式量合計 | 36282.60 |
構造登録者 | |
主引用文献 | Harris, P.A.,Boloor, A.,Cheung, M.,Kumar, R.,Crosby, R.M.,Davis-Ward, R.G.,Epperly, A.H.,Hinkle, K.W.,Hunter, R.N.,Johnson, J.H.,Knick, V.B.,Laudeman, C.P.,Luttrell, D.K.,Mook, R.A.,Nolte, R.T.,Rudolph, S.K.,Szewczyk, J.R.,Truesdale, A.T.,Veal, J.M.,Wang, L.,Stafford, J.A. Discovery of 5-[[4-[(2,3-dimethyl-2H-indazol-6-yl)methylamino]-2-pyrimidinyl]amino]-2-methyl-benzenesulfonamide (Pazopanib), a novel and potent vascular endothelial growth factor receptor inhibitor. J.Med.Chem., 51:4632-4640, 2008 Cited by PubMed: 18620382DOI: 10.1021/jm800566m 主引用文献が同じPDBエントリー |
実験手法 | X-RAY DIFFRACTION (2.15 Å) |
構造検証レポート
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