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3CJF

Crystal structure of VEGFR2 in complex with a 3,4,5-trimethoxy aniline containing pyrimidine

Summary for 3CJF
Entry DOI10.2210/pdb3cjf/pdb
Related1VR2 1Y6A 1Y6B 1ywn 3CJG
DescriptorVascular endothelial growth factor receptor 2, SULFATE ION, N~4~-(3-methyl-1H-indazol-6-yl)-N~2~-(3,4,5-trimethoxyphenyl)pyrimidine-2,4-diamine, ... (4 entities in total)
Functional Keywordsvascular endothelial growth factor receptor 2. vegfr-2, kinase insert domain receptor, protein-tyrosine kinase receptor flk-1, angiogenesis, atp-binding, developmental protein, differentiation, glycoprotein, host-virus interaction, immunoglobulin domain, membrane, nucleotide-binding, phosphoprotein, transferase, transmembrane, tyrosine-protein kinase
Biological sourceHomo sapiens (human)
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Cellular locationCell junction . Isoform 1: Cell membrane; Single-pass type I membrane protein. Isoform 2: Secreted . Isoform 3: Secreted: P35968
Total number of polymer chains1
Total formula weight36282.60
Authors
Nolte, R.T. (deposition date: 2008-03-12, release date: 2008-10-07, Last modification date: 2023-11-15)
Primary citationHarris, P.A.,Boloor, A.,Cheung, M.,Kumar, R.,Crosby, R.M.,Davis-Ward, R.G.,Epperly, A.H.,Hinkle, K.W.,Hunter, R.N.,Johnson, J.H.,Knick, V.B.,Laudeman, C.P.,Luttrell, D.K.,Mook, R.A.,Nolte, R.T.,Rudolph, S.K.,Szewczyk, J.R.,Truesdale, A.T.,Veal, J.M.,Wang, L.,Stafford, J.A.
Discovery of 5-[[4-[(2,3-dimethyl-2H-indazol-6-yl)methylamino]-2-pyrimidinyl]amino]-2-methyl-benzenesulfonamide (Pazopanib), a novel and potent vascular endothelial growth factor receptor inhibitor.
J.Med.Chem., 51:4632-4640, 2008
Cited by
PubMed: 18620382
DOI: 10.1021/jm800566m
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.15 Å)
Structure validation

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