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3CBL

Crystal structure of human feline sarcoma viral oncogene homologue (v-FES) in complex with staurosporine and a consensus peptide

Summary for 3CBL
Entry DOI10.2210/pdb3cbl/pdb
DescriptorProto-oncogene tyrosine-protein kinase Fes/Fps, Synthetic peptide, STAUROSPORINE, ... (4 entities in total)
Functional Keywordsfes, v-fes, fujinami, avian sarcoma, viral, oncogene, feline sarcoma virus, sgc, structural genomics consortium, atp-binding, kinase, nucleotide-binding, phosphoprotein, proto-oncogene, sh2 domain, transferase, tyrosine-protein kinase
Biological sourceHomo sapiens (human)
More
Total number of polymer chains2
Total formula weight44807.37
Authors
Primary citationFilippakopoulos, P.,Kofler, M.,Hantschel, O.,Gish, G.D.,Grebien, F.,Salah, E.,Neudecker, P.,Kay, L.E.,Turk, B.E.,Superti-Furga, G.,Pawson, T.,Knapp, S.
Structural Coupling of SH2-Kinase Domains Links Fes and Abl Substrate Recognition and Kinase Activation
Cell(Cambridge,Mass.), 134:793-803, 2008
Cited by
PubMed: 18775312
DOI: 10.1016/j.cell.2008.07.047
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.75 Å)
Structure validation

217705

數據於2024-03-27公開中

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