3C4H
Human poly(ADP-ribose) polymerase 3, catalytic fragment in complex with an inhibitor DR2313
Summary for 3C4H
Entry DOI | 10.2210/pdb3c4h/pdb |
Related | 2PA9 3C49 |
Descriptor | Poly(ADP-ribose) polymerase 3, 2-methyl-3,5,7,8-tetrahydro-4H-thiopyrano[4,3-d]pyrimidin-4-one, DIMETHYL SULFOXIDE, ... (4 entities in total) |
Functional Keywords | enzyme-inhibitor complex, catalytic fragment, structural genomics, structural genomics consortium, sgc, glycosyltransferase, nad, nucleus, transferase |
Biological source | Homo sapiens (human) |
Cellular location | Nucleus: Q9Y6F1 |
Total number of polymer chains | 1 |
Total formula weight | 40012.45 |
Authors | Lehtio, L.,Collins, R.,Arrowsmith, C.H.,Berglund, H.,Bountra, C.,Busam, R.,Dahlgren, L.G.,Edwards, A.M.,Flodin, S.,Flores, A.,Graslund, S.,Hammarstrom, M.,Herman, M.D.,Johansson, A.,Johansson, I.,Kallas, A.,Karlberg, T.,Kotenyova, T.,Moche, M.,Nilsson, M.E.,Nordlund, P.,Nyman, T.,Persson, C.,Sagemark, J.,Svensson, L.,Thorsell, A.G.,Tresaugues, L.,Van den Berg, S.,Welin, M.,Weigelt, J.,Structural Genomics Consortium (SGC) (deposition date: 2008-01-30, release date: 2008-02-12, Last modification date: 2023-08-30) |
Primary citation | Lehtio, L.,Jemth, A.S.,Collins, R.,Loseva, O.,Johansson, A.,Markova, N.,Hammarstrom, M.,Flores, A.,Holmberg-Schiavone, L.,Weigelt, J.,Helleday, T.,Schuler, H.,Karlberg, T. Structural basis for inhibitor specificity in human poly(ADP-ribose) polymerase-3. J.Med.Chem., 52:3108-3111, 2009 Cited by PubMed: 19354255DOI: 10.1021/jm900052j PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.1 Å) |
Structure validation
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