Human poly(ADP-ribose) polymerase 3, catalytic fragment in complex with an inhibitor DR2313

Summary for 3C4H

Related2PA9 3C49
DescriptorPoly(ADP-ribose) polymerase 3, 2-methyl-3,5,7,8-tetrahydro-4H-thiopyrano[4,3-d]pyrimidin-4-one, DIMETHYL SULFOXIDE, ... (4 entities in total)
Functional Keywordsenzyme-inhibitor complex, catalytic fragment, structural genomics, structural genomics consortium, sgc, glycosyltransferase, nad, nucleus, transferase
Biological sourceHomo sapiens (human)
Cellular locationNucleus Q9Y6F1
Total number of polymer chains1
Total molecular weight40012.45
Primary citation
Lehtio, L.,Jemth, A.S.,Collins, R.,Loseva, O.,Johansson, A.,Markova, N.,Hammarstrom, M.,Flores, A.,Holmberg-Schiavone, L.,Weigelt, J.,Helleday, T.,Schuler, H.,Karlberg, T.
Structural basis for inhibitor specificity in human poly(ADP-ribose) polymerase-3.
J.Med.Chem., 52:3108-3111, 2009
PubMed: 19354255 (PDB entries with the same primary citation)
DOI: 10.1021/jm900052j
MImport into Mendeley
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.24030.3%06.2%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

Molmil generated image of 3c4h
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Molmil generated image of 3c4h
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Molmil generated image of 3c4h
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