3C4H

Human poly(ADP-ribose) polymerase 3, catalytic fragment in complex with an inhibitor DR2313

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003950	molecular_function	NAD+ poly-ADP-ribosyltransferase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	7
Details	BINDING SITE FOR RESIDUE DRL A 601

Chain	Residue
A	HIS384
A	GLY385
A	TYR414
A	PHE415
A	SER422
A	TYR425
A	GLU514

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site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE DMS A 700

Chain	Residue
A	ARG400
A	MET402
A	GLY398
A	LEU399

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	MOD_RES: ADP-ribosyl aspartic acid => ECO:0000269|PubMed:25043379

Chain	Residue	Details
A	ASP210

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site_id	SWS_FT_FI2
Number of Residues	5
Details	MOD_RES: ADP-ribosyl glutamic acid => ECO:0000269|PubMed:25043379

Chain	Residue	Details
A	GLU231
A	GLU309
A	GLU310
A	GLU344
A	GLU449

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Catalytic Information from CSA

site_id	CSA1
Number of Residues	2
Details	Annotated By Reference To The Literature 1a26

Chain	Residue	Details
A	GLU514
A	TYR425

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