3BV9
Structure of Thrombin Bound to the Inhibitor FM19
Summary for 3BV9
Entry DOI | 10.2210/pdb3bv9/pdb |
Related | 1SFQ |
Related PRD ID | PRD_000276 |
Descriptor | Thrombin light chain, Thrombin heavy chain, FM19 inhibitor, ... (7 entities in total) |
Functional Keywords | serine protease, acute phase, blood coagulation, gamma-carboxyglutamic acid, glycoprotein, kringle, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Homo sapiens (human) |
Cellular location | Secreted, extracellular space: P00734 P00734 |
Total number of polymer chains | 3 |
Total formula weight | 34582.88 |
Authors | Nieman, M.T.,Burke, F.,Warnock, M.,Zhou, Y.,Sweigert, J.,Chen, A.,Ricketts, D.,Lucchesi, B.R.,Chen, Z.,Di Cera, E.,Hilfinger, J.,Mosberg, H.I.,Schmaier, A.H. (deposition date: 2008-01-05, release date: 2008-03-04, Last modification date: 2023-08-30) |
Primary citation | Nieman, M.T.,Burke, F.,Warnock, M.,Zhou, Y.,Sweigart, J.,Chen, A.,Ricketts, D.,Lucchesi, B.R.,Chen, Z.,Di Cera, E.,Hilfinger, J.,Kim, J.S.,Mosberg, H.I.,Schmaier, A.H. Thrombostatin FM compounds: direct thrombin inhibitors - mechanism of action in vitro and in vivo. J.Thromb.Haemost., 6:837-845, 2008 Cited by PubMed: 18315550DOI: 10.1111/j.1538-7836.2008.02937.x PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.8 Å) |
Structure validation
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