3BJI
Structural Basis of Promiscuous Guanine Nucleotide Exchange by the T-Cell Essential Vav1
Summary for 3BJI
Entry DOI | 10.2210/pdb3bji/pdb |
Related | 1F5X 1FOE |
Descriptor | Proto-oncogene vav, Ras-related C3 botulinum toxin substrate 1 precursor, ZINC ION, ... (4 entities in total) |
Functional Keywords | protein-protein interaction, gef/gtpase, atypical cysteine rich domain, guanine-nucleotide releasing factor, metal-binding, phorbol-ester binding, phosphoprotein, proto-oncogene, sh2 domain, sh3 domain, zinc, zinc-finger, adp-ribosylation, alternative splicing, gtp-binding, lipoprotein, membrane, methylation, nucleotide-binding, polymorphism, prenylation, signaling protein, structural genomics, psi-2, protein structure initiative, accelerated technologies center for gene to 3d structure, atcg3d |
Biological source | Homo sapiens (Human) More |
Cellular location | Cell membrane; Lipid-anchor; Cytoplasmic side (By similarity): P63000 |
Total number of polymer chains | 4 |
Total formula weight | 128661.33 |
Authors | Chrencik, J.E.,Brooun, A.,Kuhn, P.,Accelerated Technologies Center for Gene to 3D Structure (ATCG3D) (deposition date: 2007-12-04, release date: 2008-07-15, Last modification date: 2024-03-13) |
Primary citation | Chrencik, J.E.,Brooun, A.,Zhang, H.,Mathews, I.I.,Hura, G.L.,Foster, S.A.,Perry, J.J.,Streiff, M.,Ramage, P.,Widmer, H.,Bokoch, G.M.,Tainer, J.A.,Weckbecker, G.,Kuhn, P. Structural basis of guanine nucleotide exchange mediated by the T-cell essential Vav1. J.Mol.Biol., 380:828-843, 2008 Cited by PubMed: 18589439DOI: 10.1016/j.jmb.2008.05.024 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.6 Å) |
Structure validation
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