3BFU

Structure of the ligand-binding core of GluR2 in complex with the agonist (R)-TDPA at 1.95 A resolution

3BFU の概要

• エントリーDOI: 10.2210/pdb3bfu/pdb
• 関連するPDBエントリー: 1FTM 3BFT
• 分子名称: Glutamate receptor 2, (2R)-2-amino-3-(4-hydroxy-1,2,5-thiadiazol-3-yl)propanoic acid (3 entities in total)
• 機能のキーワード: ampa receptor, glur2, ligand-binding core, agonist, (r)-tdpa, alternative splicing, cell junction, endoplasmic reticulum, glycoprotein, ion transport, ionic channel, lipoprotein, membrane, palmitate, phosphoprotein, postsynaptic cell membrane, rna editing, synapse, transmembrane, transport, membrane protein
• 由来する生物種: Rattus norvegicus (Rat); 詳細
• 細胞内の位置: Cell membrane; Multi-pass membrane protein: P19491
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 117643.50

構造登録者

Beich-Frandsen, M.,Mirza, O.,Vestergaard, B.,Gajhede, M.,Kastrup, J.S. (登録日: 2007-11-23, 公開日: 2008-10-14, 最終更新日: 2023-11-01)

• 主引用文献: Beich-Frandsen, M.,Pickering, D.S.,Mirza, O.,Johansen, T.N.,Greenwood, J.,Vestergaard, B.,Schousboe, A.,Gajhede, M.,Liljefors, T.,Kastrup, J.S.; Structures of the ligand-binding core of iGluR2 in complex with the agonists (R)- and (S)-2-amino-3-(4-hydroxy-1,2,5-thiadiazol-3-yl)propionic acid explain their unusual equipotency.; J.Med.Chem., 51:1459-1463, 2008; PubMed: 18269227; DOI: 10.1021/jm701126w

実験手法

X-RAY DIFFRACTION (1.95 Å)