3BBR

Crystal structure of the iGluR2 ligand binding core (S1S2J-N775S) in complex with a dimeric positive modulator as well as glutamate at 2.25 A resolution

3BBR の概要

• エントリーDOI: 10.2210/pdb3bbr/pdb
• 関連するPDBエントリー: 1LBC 2AL4 2AL5
• 分子名称: Glutamate receptor 2, SULFATE ION, CHLORIDE ION, ... (7 entities in total)
• 機能のキーワード: ampa receptor, glur2, s1s2, ligand binding core, point mutation, n775s, dimeric positive modulator, agonist, cell junction, glycoprotein, ion transport, ionic channel, lipoprotein, membrane, palmitate, phosphorylation, postsynaptic cell membrane, rna editing, synapse, transmembrane, transport, membrane protein
• 由来する生物種: Rattus norvegicus (rat); 詳細
• 細胞内の位置: Cell membrane; Multi-pass membrane protein: P19491
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 59808.11

構造登録者

Kastrup, J.S.,Gajhede, M. (登録日: 2007-11-11, 公開日: 2007-12-04, 最終更新日: 2023-11-01)

• 主引用文献: Kaae, B.H.,Harpsoe, K.,Kastrup, J.S.,Sanz, A.C.,Pickering, D.S.,Metzler, B.,Clausen, R.P.,Gajhede, M.,Sauerberg, P.,Liljefors, T.,Madsen, U.; Structural proof of a dimeric positive modulator bridging two identical AMPA receptor-binding sites; Chem.Biol., 14:1294-1303, 2007; PubMed: 18022568; DOI: 10.1016/j.chembiol.2007.10.012

実験手法

X-RAY DIFFRACTION (2.25 Å)