High Resolution Crystal Structure of the Catalytic Domain of ADAMTS-5 (Aggrecanase-2)

Summary for 3B8Z

Descriptorprotein ADAMTS-5, ZINC ION, CALCIUM ION, ... (5 entities in total)
Functional Keywordsalpha/beta, hydrolase
Biological sourceHomo sapiens (human)
Cellular locationSecreted, extracellular space, extracellular matrix  Q9UNA0
Total number of polymer chains2
Total molecular weight49330.38
Shieh, H.-S.,Williams, J.M.,Mathis, K.J.,Tortorella, M.D.,Tomasselli, A. (deposition date: 2007-11-02, release date: 2007-12-11, Last modification date: 2017-10-25)
Primary citation
Shieh, H.S.,Mathis, K.J.,Williams, J.M.,Hills, R.L.,Wiese, J.F.,Benson, T.E.,Kiefer, J.R.,Marino, M.H.,Carroll, J.N.,Leone, J.W.,Malfait, A.M.,Arner, E.C.,Tortorella, M.D.,Tomasselli, A.
High resolution crystal structure of the catalytic domain of ADAMTS-5 (aggrecanase-2).
J.Biol.Chem., 283:1501-1507, 2008
PubMed: 17991750 (PDB entries with the same primary citation)
DOI: 10.1074/jbc.M705879200
MImport into Mendeley
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.21330.7%2.5%8.1%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation reportDownload
PDB entries from 2020-08-05