3B8Z
High Resolution Crystal Structure of the Catalytic Domain of ADAMTS-5 (Aggrecanase-2)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | protein ADAMTS-5 | polymer | 217 | 24034.1 | 2 | UniProt (Q9UNA0) Pfam (PF01421) | Homo sapiens (human) | A disintegrin and metalloproteinase with thrombospondin motifs 5; ADAM-TS 5; ADAM-TS5; Aggrecanase-2; ADMP-2; ADAM-TS 11 |
| 2 | C, H (A, B) | ZINC ION | non-polymer | 65.4 | 2 | Chemie (ZN) | |||
| 3 | D, E, F, I, J... (A, B) | CALCIUM ION | non-polymer | 40.1 | 6 | Chemie (CA) | |||
| 4 | G, L (A, B) | N-hydroxy-4-({4-[4-(trifluoromethyl)phenoxy]phenyl}sulfonyl)tetrahydro-2H-pyran-4-carboxamide | non-polymer | 445.4 | 2 | Chemie (294) | |||
| 5 | M, N (A, B) | water | water | 18.0 | 516 | Chemie (HOH) |
Sequence modifications
A, B: 264 - 480 (UniProt: Q9UNA0)
| PDB | External Database | Details |
|---|---|---|
| Lys 282 | Leu 282 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 48068.3 | |
| Non-Polymers* | Number of molecules | 10 |
| Total formula weight | 1262.1 | |
| All* | Total formula weight | 49330.4 |
