3B8Z
High Resolution Crystal Structure of the Catalytic Domain of ADAMTS-5 (Aggrecanase-2)
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004222 | molecular_function | metalloendopeptidase activity |
| A | 0006508 | biological_process | proteolysis |
| A | 0008237 | molecular_function | metallopeptidase activity |
| B | 0004222 | molecular_function | metalloendopeptidase activity |
| B | 0006508 | biological_process | proteolysis |
| B | 0008237 | molecular_function | metallopeptidase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE ZN A 901 |
| Chain | Residue |
| A | HIS410 |
| A | HIS414 |
| A | HIS420 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CA A 902 |
| Chain | Residue |
| A | GLU270 |
| A | ASP353 |
| A | ASP360 |
| A | CYS471 |
| A | ASP474 |
| A | HOH905 |
| site_id | AC3 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE CA A 903 |
| Chain | Residue |
| A | GLU270 |
| A | ASP353 |
| A | ASP474 |
| A | HOH916 |
| A | HOH919 |
| site_id | AC4 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CA A 904 |
| Chain | Residue |
| A | ASP369 |
| A | LEU370 |
| A | CYS376 |
| A | THR378 |
| A | GLU398 |
| A | HOH925 |
| site_id | AC5 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE ZN B 901 |
| Chain | Residue |
| B | HIS410 |
| B | HIS414 |
| B | HIS420 |
| site_id | AC6 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CA B 902 |
| Chain | Residue |
| B | GLU270 |
| B | ASP353 |
| B | ASP360 |
| B | CYS471 |
| B | ASP474 |
| B | HOH913 |
| site_id | AC7 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE CA B 903 |
| Chain | Residue |
| B | GLU270 |
| B | ASP353 |
| B | ASP474 |
| B | HOH927 |
| B | HOH971 |
| site_id | AC8 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CA B 904 |
| Chain | Residue |
| B | ASP369 |
| B | LEU370 |
| B | CYS376 |
| B | THR378 |
| B | GLU398 |
| B | HOH924 |
| site_id | AC9 |
| Number of Residues | 17 |
| Details | BINDING SITE FOR RESIDUE 294 A 801 |
| Chain | Residue |
| A | THR378 |
| A | LEU379 |
| A | GLY380 |
| A | HIS403 |
| A | PHE406 |
| A | HIS410 |
| A | GLU411 |
| A | HIS414 |
| A | HIS420 |
| A | LEU438 |
| A | SER441 |
| A | LEU443 |
| A | THR444 |
| A | SER445 |
| A | ILE446 |
| A | HOH929 |
| A | HOH1097 |
| site_id | BC1 |
| Number of Residues | 19 |
| Details | BINDING SITE FOR RESIDUE 294 B 801 |
| Chain | Residue |
| B | THR378 |
| B | LEU379 |
| B | GLY380 |
| B | HIS403 |
| B | PHE406 |
| B | THR407 |
| B | HIS410 |
| B | GLU411 |
| B | HIS414 |
| B | HIS420 |
| B | LEU438 |
| B | SER441 |
| B | LEU443 |
| B | THR444 |
| B | ILE446 |
| B | HOH932 |
| B | HOH965 |
| B | HOH1065 |
| B | HOH1142 |
Functional Information from PROSITE/UniProt
| site_id | PS00142 |
| Number of Residues | 10 |
| Details | ZINC_PROTEASE Neutral zinc metallopeptidases, zinc-binding region signature. TVAHEIGHLL |
| Chain | Residue | Details |
| A | THR407-LEU416 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 418 |
| Details | Domain: {"description":"Peptidase M12B","evidences":[{"source":"PROSITE-ProRule","id":"PRU00276","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | Active site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00276","evidenceCode":"ECO:0000255"},{"source":"PROSITE-ProRule","id":"PRU10095","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"18042673","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 6 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"18042673","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
