3AY4

Crystal structure of nonfucosylated Fc complexed with bis-glycosylated soluble form of Fc gamma receptor IIIa

Summary for 3AY4

Related2DTS 3AVE 1E4K 1T83 1T89
DescriptorIg gamma-1 chain C region, Low affinity immunoglobulin gamma Fc region receptor III-A, N-ACETYL-D-GLUCOSAMINE, ... (8 entities in total)
Functional Keywordsimmune system, complex, fc fragment, igg, receptor, cd16, gamma
Biological sourceHomo sapiens (human)
Cellular locationSecreted P01857
Cell membrane; Single-pass type I membrane protein (Potential) P08637
Total number of polymer chains3
Total molecular weight76258.82
Authors
Mizushima, T.,Takemoto, E.,Yagi, H.,Shibata-Koyama, M.,Isoda, Y.,Iida, S.,Satoh, M.,Kato, K. (deposition date: 2011-04-28, release date: 2011-08-03, Last modification date: 2011-11-09)
Primary citation
Mizushima, T.,Yagi, H.,Takemoto, E.,Shibata-Koyama, M.,Isoda, Y.,Iida, S.,Masuda, K.,Satoh, M.,Kato, K.
Structural basis for improved efficacy of therapeutic antibodies on defucosylation of their Fc glycans
Genes Cells, 16:1071-1080, 2011
PubMed: 22023369 (PDB entries with the same primary citation)
DOI: 10.1111/j.1365-2443.2011.01552.x
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.2 Å)
NMR Information
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.26090.5%4.0%6.1%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation reportDownload