3ARA
Discovery of Novel Uracil Derivatives as Potent Human dUTPase Inhibitors
Summary for 3ARA
Entry DOI | 10.2210/pdb3ara/pdb |
Related | 1Q5H 2HQU 3EHW |
Descriptor | Deoxyuridine 5'-triphosphate nucleotidohydrolase, 1-[3-({(2R)-2-[hydroxy(diphenyl)methyl]pyrrolidin-1-yl}sulfonyl)propyl]pyrimidine-2,4(1H,3H)-dione, MAGNESIUM ION, ... (4 entities in total) |
Functional Keywords | hydrolase, magnesium binding, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Homo sapiens (human) |
Cellular location | Isoform 2: Nucleus . Isoform 3: Mitochondrion : P33316 |
Total number of polymer chains | 3 |
Total formula weight | 54770.47 |
Authors | Chong, K.T.,Miyakoshi, H.,Miyahara, S.,Fukuoka, M. (deposition date: 2010-11-25, release date: 2010-12-08, Last modification date: 2024-03-13) |
Primary citation | Miyakoshi, H.,Miyahara, S.,Yokogawa, T.,Chong, K.T.,Taguchi, J.,Endoh, K.,Yano, W.,Wakasa, T.,Ueno, H.,Takao, Y.,Nomura, M.,Shuto, S.,Nagasawa, H.,Fukuoka, M. Synthesis and discovery of N-carbonylpyrrolidine- or N-sulfonylpyrrolidine-containing uracil derivatives as potent human deoxyuridine triphosphatase inhibitors J.Med.Chem., 55:2960-2969, 2012 Cited by PubMed: 22404301DOI: 10.1021/jm201627n PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.7 Å) |
Structure validation
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