3ARA
Discovery of Novel Uracil Derivatives as Potent Human dUTPase Inhibitors
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C (A, B, C) | Deoxyuridine 5'-triphosphate nucleotidohydrolase | polymer | 164 | 17771.1 | 3 | UniProt (P33316) Pfam (PF00692) | Homo sapiens (human) | DUT-N, dUTPase, dUTP pyrophosphatase |
| 2 | D, F, H (A, B, C) | 1-[3-({(2R)-2-[hydroxy(diphenyl)methyl]pyrrolidin-1-yl}sulfonyl)propyl]pyrimidine-2,4(1H,3H)-dione | non-polymer | 469.6 | 3 | Chemie (MKH) | |||
| 3 | E, G (A, B) | MAGNESIUM ION | non-polymer | 24.3 | 2 | Chemie (MG) | |||
| 4 | I, J, K (A, B, C) | water | water | 18.0 | 387 | Chemie (HOH) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 53313.2 | |
| Non-Polymers* | Number of molecules | 5 |
| Total formula weight | 1457.3 | |
| All* | Total formula weight | 54770.5 |
