3ARA
Discovery of Novel Uracil Derivatives as Potent Human dUTPase Inhibitors
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0000287 | molecular_function | magnesium ion binding |
A | 0004170 | molecular_function | dUTP diphosphatase activity |
A | 0006226 | biological_process | dUMP biosynthetic process |
A | 0046081 | biological_process | dUTP catabolic process |
B | 0000287 | molecular_function | magnesium ion binding |
B | 0004170 | molecular_function | dUTP diphosphatase activity |
B | 0006226 | biological_process | dUMP biosynthetic process |
B | 0046081 | biological_process | dUTP catabolic process |
C | 0000287 | molecular_function | magnesium ion binding |
C | 0004170 | molecular_function | dUTP diphosphatase activity |
C | 0006226 | biological_process | dUMP biosynthetic process |
C | 0046081 | biological_process | dUTP catabolic process |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 13 |
Details | BINDING SITE FOR RESIDUE MKH A 165 |
Chain | Residue |
A | ALA98 |
A | HOH195 |
A | HOH222 |
C | SER86 |
C | ALA90 |
A | GLY99 |
A | VAL100 |
A | TYR105 |
A | VAL109 |
A | GLY110 |
A | VAL112 |
A | GLN146 |
A | HOH173 |
site_id | AC2 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE MG A 166 |
Chain | Residue |
A | GLU135 |
B | GLU135 |
B | HOH168 |
C | GLU135 |
site_id | AC3 |
Number of Residues | 12 |
Details | BINDING SITE FOR RESIDUE MKH B 165 |
Chain | Residue |
A | SER86 |
B | LYS67 |
B | ALA98 |
B | GLY99 |
B | VAL100 |
B | TYR105 |
B | VAL109 |
B | GLY110 |
B | VAL112 |
B | HOH172 |
B | HOH206 |
B | HOH271 |
site_id | AC4 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE MG B 166 |
Chain | Residue |
A | HIS34 |
B | HIS34 |
C | HIS34 |
site_id | AC5 |
Number of Residues | 11 |
Details | BINDING SITE FOR RESIDUE MKH C 165 |
Chain | Residue |
B | SER86 |
B | ALA90 |
C | VAL65 |
C | GLY99 |
C | VAL100 |
C | TYR105 |
C | VAL109 |
C | GLY110 |
C | VAL112 |
C | HOH167 |
C | HOH293 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 9 |
Details | BINDING: BINDING => ECO:0000269|PubMed:8805593, ECO:0000305|PubMed:17880943, ECO:0007744|PDB:1Q5H, ECO:0007744|PDB:2HQU, ECO:0007744|PDB:3EHW |
Chain | Residue | Details |
A | ARG85 | |
A | ARG153 | |
A | PHE158 | |
B | ARG85 | |
B | ARG153 | |
B | PHE158 | |
C | ARG85 | |
C | ARG153 | |
C | PHE158 |
site_id | SWS_FT_FI2 |
Number of Residues | 6 |
Details | BINDING: BINDING => ECO:0000269|PubMed:8805593, ECO:0000305|PubMed:17880943, ECO:0007744|PDB:1Q5H, ECO:0007744|PDB:2HQU, ECO:0007744|PDB:3ARA, ECO:0007744|PDB:3ARN, ECO:0007744|PDB:3EHW |
Chain | Residue | Details |
A | GLY99 | |
A | GLY110 | |
B | GLY99 | |
B | GLY110 | |
C | GLY99 | |
C | GLY110 |
site_id | SWS_FT_FI3 |
Number of Residues | 3 |
Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:23186163, ECO:0007744|PubMed:24275569 |
Chain | Residue | Details |
A | LEU88 | |
B | LEU88 | |
C | LEU88 |
site_id | SWS_FT_FI4 |
Number of Residues | 3 |
Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163 |
Chain | Residue | Details |
A | SER11 | |
B | SER11 | |
C | SER11 |