3AQV

Human AMP-activated protein kinase alpha 2 subunit kinase domain (T172D) complexed with compound C

3AQV の概要

• エントリーDOI: 10.2210/pdb3aqv/pdb
• 関連するPDBエントリー: 2h6d 2yza
• 分子名称: 5'-AMP-activated protein kinase catalytic subunit alpha-2, 6-[4-(2-piperidin-1-ylethoxy)phenyl]-3-pyridin-4-ylpyrazolo[1,5-a]pyrimidine (3 entities in total)
• 機能のキーワード: structural genomics, riken structural genomics/proteomics initiative, rsgi, transferase, signaling protein, serine/threonine protein kinase, phosphorylation, atp-binding, nucleotide-binding, cholesterol biosynthesis, fatty acid biosynthesis, lipid synthesis, glucose metabolism, magnesium, metal-binding, serine/threonine-protein kinase, steroid biosynthesis, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Cytoplasm (By similarity): P54646
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 31971.22

構造登録者

Handa, N.,Takagi, T.,Saijo, S.,Kishishita, S.,Toyama, M.,Terada, T.,Shirouzu, M.,Yokoyama, S.,RIKEN Structural Genomics/Proteomics Initiative (RSGI) (登録日: 2010-11-19, 公開日: 2011-04-27, 最終更新日: 2023-11-01)

• 主引用文献: Handa, N.,Takagi, T.,Saijo, S.,Kishishita, S.,Takaya, D.,Toyama, M.,Terada, T.,Shirouzu, M.,Suzuki, A.,Lee, S.,Yamauchi, T.,Okada-Iwabu, M.,Iwabu, M.,Kadowaki, T.,Minokoshi, Y.,Yokoyama, S.; Structural basis for compound C inhibition of the human AMP-activated protein kinase alpha 2 subunit kinase domain; Acta Crystallogr.,Sect.D, 67:480-487, 2011; PubMed: 21543851; DOI: 10.1107/S0907444911010201

実験手法

X-RAY DIFFRACTION (2.08 Å)