Crystal structure of 1-deoxy-D-xylulose 5-phosphate reductoisomerase (DXR) complexed with pyridin-2-ylmethylphosphonic acid

Summary for 3ANL

Related2EGH 1T1R 1T1S 1JVS 3ANM 3ANN
Descriptor1-deoxy-D-xylulose 5-phosphate reductoisomerase, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, (pyridin-2-ylmethyl)phosphonic acid, ... (4 entities in total)
Functional Keywordsreductoisomerase, nadph binding, oxidoreductase
Biological sourceEscherichia coli
Total number of polymer chains2
Total molecular weight93329.8
Endo, K.,Kato, M.,Deng, L.,Song, Y.,Yajima, S. (deposition date: 2010-09-03, release date: 2011-02-23, Last modification date: 2011-10-19)
Primary citation
Deng, L.,Endo, K.,Kato, M.,Cheng, G.,Yajima, S.,Song, Y.
Structures of 1-Deoxy-D-Xylulose-5-Phosphate Reductoisomerase/Lipophilic Phosphonate Complexes
ACS Med Chem Lett, 2:165-170, 2011
PubMed: 21379374 (PDB entries with the same primary citation)
DOI: 10.1021/ml100243r
MImport into Mendeley
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.227100.4%7.0%5.6%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation reportDownload
PDB entries from 2020-08-05