3ZC5
X-ray Structure of c-Met kinase in complex with inhibitor (S)-6-(1-(6- (1-methyl-1H-pyrazol-4-yl)-(1,2,4)triazolo(4,3-b)pyridazin-3-yl)ethyl) quinoline.
Summary for 3ZC5
Entry DOI | 10.2210/pdb3zc5/pdb |
Related | 3ZBX |
Descriptor | HEPATOCYTE GROWTH FACTOR RECEPTOR, 6-{(1S)-1-[6-(1-methyl-1H-pyrazol-4-yl)[1,2,4]triazolo[4,3-b]pyridazin-3-yl]ethyl}quinoline (3 entities in total) |
Functional Keywords | transferase, kinase, inhibitor |
Biological source | HOMO SAPIENS (HUMAN) |
Total number of polymer chains | 1 |
Total formula weight | 35234.81 |
Authors | McTigue, M.,Grodsky, N.,Ryan, K. (deposition date: 2012-11-15, release date: 2013-11-27, Last modification date: 2023-12-20) |
Primary citation | Cui, J.J.,Shen, H.,Tran-Dube, M.,Nambu, M.,Mctigue, M.,Grodsky, N.,Ryan, K.,Yamazaki, S.,Aguirre, S.,Parker, M.,Li, Q.,Zou, H.,Christensen, J. Lessons from (S)-6-(1-(6-(1-Methyl-1H-Pyrazol-4-Yl)-[1,2, 4]Triazolo[4,3-B]Pyridazin-3-Yl)Ethyl)Quinoline (Pf-04254644), an Inhibitor of Receptor Tyrosine Kinase C-met with High Protein Kinase Selectivity But Broad Phosphodiesterase Family Inhibition Leading to Myocardial Degeneration in Rats. J.Med.Chem., 56:6651-, 2013 Cited by PubMed: 23944843DOI: 10.1021/JM400926X PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.2 Å) |
Structure validation
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