3WT5
A mixed population of antagonist and agonist binding conformers in a single crystal explains partial agonism against vitamin D receptor: Active vitamin D analogues with 22R-alkyl group
Summary for 3WT5
Entry DOI | 10.2210/pdb3wt5/pdb |
Related | 3WT6 3WT7 |
Descriptor | Vitamin D3 receptor, Mediator of RNA polymerase II transcription subunit 1, (1R,3R,7E,17beta)-17-[(2R,3R)-3-butyl-6-hydroxy-6-methylheptan-2-yl]-2-methylidene-9,10-secoestra-5,7-diene-1,3-diol, ... (4 entities in total) |
Functional Keywords | transcription, vitamin d3, vdre, rxr, co-factors, nuclear |
Biological source | Rattus norvegicus (rats) More |
Cellular location | Nucleus: P13053 Q15648 |
Total number of polymer chains | 2 |
Total formula weight | 32638.68 |
Authors | Anami, Y.,Itoh, T.,Yamamoto, K. (deposition date: 2014-04-08, release date: 2014-06-11, Last modification date: 2024-03-20) |
Primary citation | Anami, Y.,Itoh, T.,Egawa, D.,Yoshimoto, N.,Yamamoto, K. A Mixed Population of Antagonist and Agonist Binding Conformers in a Single Crystal Explains Partial Agonism against Vitamin D Receptor: Active Vitamin D Analogues with 22R-Alkyl Group. J.Med.Chem., 57:4351-4367, 2014 Cited by PubMed: 24742174DOI: 10.1021/jm500392t PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.9 Å) |
Structure validation
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