3WT7

Crystal structure of VDR-LBD complexed with 22R-Butyl-2-methylidene-26,27-dimethyl-19,24-dinor-1 ,25-dihydroxyvitamin D3

Summary for 3WT7

• Entry DOI: 10.2210/pdb3wt7/pdb
• Related: 3WT5 3WT6
• Descriptor: Vitamin D3 receptor, Mediator of RNA polymerase II transcription subunit 1, (1R,3R,7E,17beta)-17-[(2R,3R)-3-butyl-5-ethyl-5-hydroxyheptan-2-yl]-2-methylidene-9,10-secoestra-5,7-diene-1,3-diol, ... (4 entities in total)
• Functional Keywords: transcription, vitamin d3, vdre, rxr, co-factors, nuclear
• Biological source: Rattus norvegicus (rats); More
• Cellular location: Nucleus: P13053 Q15648
• Total number of polymer chains: 2
• Total formula weight: 32652.70

Authors

Anami, Y.,Itoh, T.,Yamamoto, K. (deposition date: 2014-04-08, release date: 2014-06-11, Last modification date: 2023-11-08)

• Primary citation: Anami, Y.,Itoh, T.,Egawa, D.,Yoshimoto, N.,Yamamoto, K.; A Mixed Population of Antagonist and Agonist Binding Conformers in a Single Crystal Explains Partial Agonism against Vitamin D Receptor: Active Vitamin D Analogues with 22R-Alkyl Group.; J.Med.Chem., 57:4351-4367, 2014; PubMed: 24742174; DOI: 10.1021/jm500392t

Experimental method

X-RAY DIFFRACTION (2.4 Å)