3UZA
Thermostabilised Adenosine A2A receptor in complex with 6-(2,6-Dimethylpyridin-4-yl)-5-phenyl-1,2,4-triazin-3-amine
Summary for 3UZA
Entry DOI | 10.2210/pdb3uza/pdb |
Related | 3PWH 3REY 3RFM 3UZC |
Descriptor | Adenosine receptor A2a, 6-(2,6-dimethylpyridin-4-yl)-5-phenyl-1,2,4-triazin-3-amine (2 entities in total) |
Functional Keywords | 7tm, gpcr, signaling protein, g-protein, membrane protein |
Biological source | Homo sapiens (human) |
Cellular location | Cell membrane; Multi-pass membrane protein: P29274 |
Total number of polymer chains | 1 |
Total formula weight | 36756.43 |
Authors | Congreve, M.,Andrews, S.P.,Dore, A.S.,Hollenstein, K.,Hurrell, E.,Langmead, C.J.,Mason, J.S.,Ng, I.W.,Tehan, B.,Zhukov, A.,Weir, M.,Marshall, F.H. (deposition date: 2011-12-07, release date: 2012-03-21, Last modification date: 2023-11-08) |
Primary citation | Congreve, M.,Andrews, S.P.,Dore, A.S.,Hollenstein, K.,Hurrell, E.,Langmead, C.J.,Mason, J.S.,Ng, I.W.,Tehan, B.,Zhukov, A.,Weir, M.,Marshall, F.H. Discovery of 1,2,4-Triazine Derivatives as Adenosine A(2A) Antagonists using Structure Based Drug Design J.Med.Chem., 55:1898-1903, 2012 Cited by PubMed: 22220592DOI: 10.1021/jm201376w PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.273 Å) |
Structure validation
Download full validation report