3UH4
TANKYRASE-1 complexed with NVP-XAV939
Summary for 3UH4
Entry DOI | 10.2210/pdb3uh4/pdb |
Related | 3UH2 |
Descriptor | Tankyrase-1, ZINC ION, 2-[4-(trifluoromethyl)phenyl]-7,8-dihydro-5H-thiopyrano[4,3-d]pyrimidin-4-ol, ... (6 entities in total) |
Functional Keywords | transferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (human) |
Cellular location | Cytoplasm: O95271 |
Total number of polymer chains | 2 |
Total formula weight | 52523.58 |
Authors | |
Primary citation | Kirby, C.A.,Cheung, A.,Fazal, A.,Shultz, M.D.,Stams, T. Structure of human tankyrase 1 in complex with small-molecule inhibitors PJ34 and XAV939. Acta Crystallogr.,Sect.F, 68:115-118, 2012 Cited by PubMed: 22297980DOI: 10.1107/S1744309111051219 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2 Å) |
Structure validation
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