3U4W

Src in complex with DNA-templated macrocyclic inhibitor MC4b

Summary for 3U4W

• Entry DOI: 10.2210/pdb3u4w/pdb
• Related: 3U51
• Related PRD ID: PRD_001022
• Descriptor: Proto-oncogene tyrosine-protein kinase Src, macrocyclic inhibitor MC4B, GLYCEROL, ... (5 entities in total)
• Functional Keywords: protein kinase, src-like inactive conformation, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• Biological source: Gallus gallus (chicken)
• Total number of polymer chains: 2
• Total formula weight: 33050.75

Authors

Seeliger, M.A.,Liu, D.R.,Georghiou, G.,Kleiner, R.E.,Pulkoski-Gross, M. (deposition date: 2011-10-10, release date: 2012-02-22, Last modification date: 2023-11-15)

• Primary citation: Georghiou, G.,Kleiner, R.E.,Pulkoski-Gross, M.,Liu, D.R.,Seeliger, M.A.; Highly specific, bisubstrate-competitive Src inhibitors from DNA-templated macrocycles.; Nat.Chem.Biol., 8:366-374, 2012; PubMed: 22344177; DOI: 10.1038/nchembio.792

Experimental method

X-RAY DIFFRACTION (1.9 Å)