3U51
Src in complex with DNA-templated macrocyclic inhibitor MC1
Summary for 3U51
| Entry DOI | 10.2210/pdb3u51/pdb |
| Related | 3U4W |
| Related PRD ID | PRD_001023 |
| Descriptor | Proto-oncogene tyrosine-protein kinase Src, macrocyclic inhibitor MC1 (3 entities in total) |
| Functional Keywords | protein kinase, src-like inactive conformation, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
| Biological source | Gallus gallus (chicken) |
| Total number of polymer chains | 4 |
| Total formula weight | 64636.39 |
| Authors | Seeliger, M.A.,Liu, D.R.,Georghiou, G.,Kleiner, R.E.,Pulkoski-Gross, M. (deposition date: 2011-10-10, release date: 2012-02-22, Last modification date: 2023-11-15) |
| Primary citation | Georghiou, G.,Kleiner, R.E.,Pulkoski-Gross, M.,Liu, D.R.,Seeliger, M.A. Highly specific, bisubstrate-competitive Src inhibitors from DNA-templated macrocycles. Nat.Chem.Biol., 8:366-374, 2012 Cited by PubMed: 22344177DOI: 10.1038/nchembio.792 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.241 Å) |
Structure validation
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