3U4W

Src in complex with DNA-templated macrocyclic inhibitor MC4b

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004672	molecular_function	protein kinase activity
A	0004713	molecular_function	protein tyrosine kinase activity
A	0005524	molecular_function	ATP binding
A	0006468	biological_process	protein phosphorylation

Functional Information from PDB Data

site_id	AC1
Number of Residues	8
Details	BINDING SITE FOR RESIDUE GOL A 601

Chain	Residue
A	GLU280
A	THR296
A	LEU297
A	PRO333
A	GLY465
A	MET466
A	VAL467
A	HOH751

---

site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 A 602

Chain	Residue
A	GOL607
A	HOH783
A	HOH811
A	ARG264

---

site_id	AC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 A 603

Chain	Residue
A	LYS272
A	LYS351
A	HOH899
A	HOH908
A	HOH994

---

site_id	AC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 A 604

Chain	Residue
A	HIS319
A	SER372
A	GLN513
A	HOH753
A	HOH921

---

site_id	AC5
Number of Residues	7
Details	BINDING SITE FOR RESIDUE SO4 A 605

Chain	Residue
A	TYR340
A	MET341
A	SER342
A	GLY395
A	GLU396
A	HOH831
A	HOH955

---

site_id	AC6
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 A 606

Chain	Residue
A	PRO488
A	GLU489
A	HOH711
A	HOH982
A	HOH1004

---

site_id	AC7
Number of Residues	5
Details	BINDING SITE FOR RESIDUE GOL A 607

Chain	Residue
A	PRO263
A	ARG264
A	GLU265
A	SO4602
A	HOH885

---

site_id	AC8
Number of Residues	4
Details	BINDING SITE FOR RESIDUE GOL A 608

Chain	Residue
A	SER303
A	PRO304
A	GLU305
A	HOH971

---

site_id	AC9
Number of Residues	25
Details	BINDING SITE FOR CHAIN B OF MACROCYCLIC INHIBITOR MC4B

Chain	Residue
A	GLY274
A	GLN275
A	GLY276
A	CYS277
A	PHE278
A	GLY279
A	GLU280
A	VAL281
A	ALA293
A	LYS295
A	LEU297
A	GLU339
A	MET341
A	GLY344
A	ASP386
A	ARG388
A	LEU393
A	ASP404
A	ALA408
A	ILE411
A	HOH704
A	HOH706
A	HOH746
A	HOH953
B	HOH102

---

Functional Information from PROSITE/UniProt

site_id	PS00107
Number of Residues	23
Details	PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. LGQGCFGEVWmGtwngttr...........VAIK

Chain	Residue	Details
A	LEU273-LYS295

---

site_id	PS00109
Number of Residues	13
Details	PROTEIN_KINASE_TYR Tyrosine protein kinases specific active-site signature. YVHrDLRAANILV

Chain	Residue	Details
A	TYR382-VAL394

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	253
Details	Domain: {"description":"Protein kinase","evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	1
Details	Active site: {"description":"Proton acceptor","evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"},{"source":"PROSITE-ProRule","id":"PRU10028","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	8
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	1
Details	Binding site: {}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	1
Details	Modified residue: {"description":"Phosphotyrosine; by autocatalysis","evidences":[{"source":"PubMed","id":"6273838","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8856081","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	1
Details	Modified residue: {"description":"Phosphotyrosine; by autocatalysis","evidences":[{"source":"PubMed","id":"8856081","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	1
Details	Modified residue: {"description":"S-nitrosocysteine","evidences":[{"source":"PubMed","id":"19948721","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	1
Details	Modified residue: {"description":"Phosphotyrosine; by CSK","evidences":[{"source":"PubMed","id":"2420005","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---