3TZA

Crystal structure of the GluA2 ligand-binding domain (S1S2J) in complex with the antagonist (S)-2-amino-3-(2-(2-carboxyethyl)-5-chloro-4-nitrophenyl)propionic acid at 1.9A resolution

Summary for 3TZA

Entry DOI	10.2210/pdb3tza/pdb
Related	1FTL 1N0T
Descriptor	Glutamate receptor 2,Glutamate receptor 2, (S)-2-amino-3-(2-(2-carboxyethyl)-5-chloro-4-nitrophenyl)propionic acid, SULFATE ION, ... (4 entities in total)
Functional Keywords	ampa receptor ligand-binding domain, glua2-s1s2j, antagonist, membrane protein
Biological source	Rattus norvegicus (Rat) More
Cellular location	Cell membrane; Multi-pass membrane protein: P19491
Total number of polymer chains	2
Total formula weight	59461.00
Authors	Frydenvang, K.,Kastrup, J.S. (deposition date: 2011-09-27, release date: 2011-10-26, Last modification date: 2023-11-01)
Primary citation	Szymanska, E.,Frydenvang, K.,Contreras-Sanz, A.,Pickering, D.S.,Frola, E.,Serafimoska, Z.,Nielsen, B.,Kastrup, J.S.,Johansen, T.N. A new phenylalanine derivative acts as an antagonist at the AMPA receptor GluA2 and introduces partial domain closure: synthesis, resolution, pharmacology, and crystal structure J.Med.Chem., 54:7289-7298, 2011 Cited by PubMed: 21923187 DOI: 10.1021/jm200862h PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.9 Å)

Structure validation